Radiation Dose Enhancement in Megavoltage Radiation Therapy using Au, Gd, Pt, Ag, and Bi Nanoparticles of Various Concentration Level

A digital phantom was created from a CT scan of patient’s head and employed together with GATE 8.2 Monte Carlo modeling linear accelerator nominal 6 MV energy to simulate an irradiation geometry for typical tumor volume centrally within the brain region. Although simplistic in arrangement, this setup considered appropriate demonstrate dose enhancements that may be expected megavoltage external beam radiation therapy nanoparticles (NP) different elemental composition concentration. Ag, Gd, Pt, Au Bi were modeled concentrations varying 15 mg NP / gram tissue 70 tissue. The maximum Average Dose Enhancement Factor (ADEF) Gross Tumour Volume (GTV) observed 3 % Bi.